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Abstract Chronic inflammation is the main risk for cardiovascular disease in the end-stage renal disease patients, moreover, it constitutes an important risk factor in the onset and progression of atherosclerotic lesions. C-reactive protein is an excellent marker of systemic inflammation. The aim of our study is to test the correlation of inflammatory markers principally C-reactive protein with the cardiovascular risk factors principally left ventricular hypertrophy and their link to both adequacy of dialysis and nutritional status of hemodialysis patients. The material of this work comprised twenty-six patients with end stage renal disease undergoing maintenance hemodialysis. The age of patients ranged from 18 to 70 years among them 11 cases were females and 15 Were males. All of them were subjected to a thorough clinical, laboratory investigations including evaluation of c-reactive protein and assessment of dialysis and nutritional status by the use of urea kinetic modeling besides cardiovascular assessment by meticulous echocardiographic examination as well as assessment of carotid artery by ultrasound evaluation. Furthermore, all patients were subcategorized according to CRP as normal CRP group and elevated CRP group. Although we did not find a significant correlation between high CRP and echocardiographic parameters. High CRP was associated with a significant increase in the incidence of carotid calcification. Moreover, Our study showed a strong association between CRP and mortality in patients maintained on regular hemodialysis. The incidence of mortality was high , 3 out of 9 cause with high CRP level died ( 33% ) meanwhile no mortality was detected among 17 cases with the normal CRP level. |