الفهرس 
Bone metabolismOnly 14 pages are availabe for public view
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Abstract
Osteopenia and/or osteoprosis are major causes of morbidity in thalassemic patients who survive longer as a result of improved treatment. The etiology of bone disease in thalassemia is multifactorial and is still under investigation. Over the recent years, the ever increasing morbidity of bone disease among the thalassemic patients leads to reconsidering both the diagnostic and therapeutic facet of this problem in the hope that this information would help to determine their appropriate treatment. Determination of bone markers either of bone formation or bone resorption contributes to the assessment of bone loss. The aim of this work is to characterize some biochemical parameters that affect bone formation metabolism in thalassemic children. This study comprised 56 subjects, 36 ?-thalassemia patients besides 20 apparantly healthy controls of matched age and sex. They were selected from Hematology unit of Mansoura Children Hospital. 9All patients were subjected to: accurate history taking, thorough clinical examination and laboratory investigations as CBC, peripheral blood smears, Reticulocytic count, Hemoglobin electrophoresis, serum iron, serum ferritin and serum TIBC, Serum calcium and serum phosphorus, serum alkaline phosphatase and osteocalcin. The results of this study as regard hematological parameters revealed low hemoglobin level. Microcytic hypochromic anemia. Reticulocytosis. High TLC. The other laboratory data revealed high serum Fe and ferritin. Serum calcium level was within normal range. Serum phosphorus level was higher in thalassemic patients than the control. Serum alkaline phosphatase level showed no statistical significance between the patient and control but it was slightly higher in thalassemic patients than the control. Osteocalcin serum level was lower than the control.