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العنوان
Expression of (C erbB 2) oncoprotein and heat shock protein 27 HSP 27 in Oral Sell Carcinoma :
المؤلف
Zyada, Manal Mohamed.
هيئة الاعداد
باحث / منال محمد محمد زيادة
مشرف / ناديه مصطفى كمال لطفي
مشرف / عزة عباس السيسي
مشرف / هانم عبدالفتاح صقر
مناقش / مها محمد ابوهاشم
الموضوع
Oral Pathology. Heat shock proteins.
تاريخ النشر
2001.
عدد الصفحات
191 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
طب الأسنان
تاريخ الإجازة
1/1/2001
مكان الإجازة
جامعة المنصورة - كلية طب الأسنان - قسم باثولوجيا الفم
الفهرس
Only 14 pages are availabe for public view

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from 213

Abstract

Oral cancer is squamous cells of the most common cancers of the mouth and while each of the assessment is gradient microscopy and clinical stage of the tumor of the most important factors to determine the course synchronized condition but research has shown that these factors are lack of privacy as well as accuracy.
Has accumulated in recent years strong evidence because the turmoil in the installation Aonchat genes Almtsrtunh play a role in the occurrence of some of oncology such as Jane C-erbB-2 as it turns out , the response to treatments that mean the elimination of some tumors varied results based on the appearance of some proteins and these are called proteins anti- drugs , including heat shock protein HSP-27.
As well as the response of patients to treatment used also means on the other hand .
from this research , we can draw the following :
1 - The study immune Alheistokimaaúah to monitor the presence of protein C - erbB and Brhtin the thermal shock HSP-27 highways and relatively easy and can be applied to slides Tabravenyh .
2 - There is a direct correlation between the presence of Barhtin CerbB-2 and the total points microscopic cancer cases , as well as with the severity of the cancer stage oral squamous cells.
3 - indicates the presence of protein C -erbB-2 to the aggressive behavior of oral squamous cancer cells and therefore is the emergence of this protein index towards bad development potential of the tumor .
For this , these results led to the following recommendations:
1 - It is recommended to monitor and evaluate the protein C-erbB-2 in cases of oral cancer, squamous cell and considering the degree appearances mark and another indication of what a gap expected from the course of the disease and index important and additional next to traditional ways of checking microscopic and clinical evaluation helps in choosing the optimal treatment for each patient.
2 - It is recommended directing some research Ngo attempt to control the level of the emergence of the HSP-27 protein through gene therapy , hoping to increase the sensitivity of cancer cells targeted for the treatment and eradication of the tumor in the best of ways.