الفهرس 
The coagulation systemOnly 14 pages are availabe for public view
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Abstract
Cardiopulmonary bypass has been known for a long time to produce a coagulopathy, especially if prolonged. Wide spread use of CPB has rejuvenated awareness of catastrophic intraoperative or postoperative hemorrhage that may lead to significant morbidity and mortality . This study was designed to evaluate the minimal effective dose of tranexamic acid on peri-operative bleeding and allogenic transfusion in patients undergoing cardiopulmonary bypass for elective valve replacement surgery. It was found that when tranexamic acidwas given as a bolus of 1 g over 20 minutes after the induction of anesthesia, but before skin incision, and a continuous infusion of 400 mg/hr during the whole surgical time significantly decrease the perioperative bleeding and the need for allogenic blood transfusion in open heart surgery.