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Abstract The present study was designed to reveal the possible disturbances which may occur in the hypothalamic - pituitary - gonadal axis in insulin dependent diabetes mellitus (IDDM), to suggest the possible mechanisms which may occur in IDDM patients and to suggest the possible solutions or sexual problems in diabetic men and women. This study was carried out on: 1- 15 male diabetic patients with normal sexual function. 2- 15 male diabetic patients with impotence 3- 15 male health persons used as control male group. 4- 15 female diabetic patients with normal menstrual cycle. 5- 15 female diabetic patients with menstrual disorders. 6- 15 female health persons used as control female group. Fasting venous blood samples were withdrawn from control group and diabetic female patients with normal menstrual cycle at day 3-5 of their menstrual cycle and were subjected to the following investigations. 1-Fasting blood sugar (F.B.S). 2- Follicle stimulating hormone (FSH). 3- Luteinizing hormone (LH). 4- Prolactin (PRL). 5- Estradiol 6- Total cholesterol (T-CHOL). 7- Triglyccrades (TG). 8- High density lipoprotein-cholesterol (HDL-C) 9- Low density lipoprotein-cholesterol (LDL-C). At 21” of the cycle (midluteal phase), fasting venous blood samples were withdrawn for estimation of progesterone. For diabetic female patients who suffered from menstual disorders, one blood sample was withdrawn from each diabetic female for estimation of 1- F.B.S 2- FSH 3- LH 4- PRL 5- Estradiol 6- Progesterone7- T-CHOL 8- TG 9- HDL-C 10- LDL-C . |