الفهرس 
INTRODUCTION and Aim of the work.Only 14 pages are availabe for public view
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Abstract
Background: Hepatocyte injury is encountered frequently in the practice of medicine. The biochemical markers of hepatic injury were classified into markers of necrosis (AST, ALT, ALP and LDH) and markers of regeneration (RBP, AFP, GGT and DCP). Aim of work: The present work was designed aiming to assess the value of using the serum biomarkers of hepatocyte regeneration together with the serum biomarkers of hepatocyte necrosis to predict the clinical outcome in cases of acute hepatitis and to detect a possible correlation between the markers of hepatocyte regeneration and necrosis. Methods: The serum markers of hepatocyte regeneration and necrosis were assessed in 20 patients with acute viral hepatitis A at the end of the first week of illness and two weeks later in addition to 10 healthy volunteers as a control group. Results: A significant reduction in the levels of AST, ALT, ALP, and GGT with a significant elevation of AFP & RBP levels in patients at second in comparison to initial assessment and to the control group. Conclusion: Patients with acute hepatitis who demonstrate a significant decline in the serum levels of the necrosis markers (specially AST and ALT) with a concomitant elevation in the levels of the regeneration markers (RBP and AFP) and a significant reduction in serum GGT are more likely to have a complete and rapid recovery.