الفهرس 
Introduction
OzoneOnly 14 pages are availabe for public view
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Abstract
The purpose of the present study is to evaluate the role and effectiveness of the treatment with ozone in protecting rats intoxicated with different poisons.
So, this study comprised 5 groups, each of the first 4 groups composed of 45 male-albino rats
The 1st group was given nephrotoxic poison (CdCl2).
The 2nd group was given hepatotoxic poison (CCl4).
The 3rd group was given neurotoxic poison (diazinon).
The 4th group was given CNS toxic drug (phenobarbitone).
After intoxication development, 15 animals were isolated from each group to be considered as a toxic group, the remaining 30 animals were subdivided into two subgroups. The 1st subgroups were treated with atoxic dose of mixture of O2-O3.
The other subgroups were given placebo (nitrogen).
The 5th group composed of 15 male albino rats, they served as a normal control group. After the end of each experiment, the animals of each group were weighed, sacrificed, and blood sample was taken for estimation of:
• Liver function tests: albumin, total protein, SGOT and SGPT).
• Serum creatinine.
• Specific hepatic enzymes activities ( cholinesterase and GT)
The results were compared and statistically analysed.
The rats were then dissected, livers and kidneys were taken for histopathological studies.
Conclusion: Conclusion from this work that, the 4 poisons (cadmium, CCl4, diazinon, and phenobarbitone overdose) have a pronounced experimental toxic effects, producing necrotic injury on the rats liver and kidneys. These were reflected on biochemical liver and kidney function tests. These changes may be due to oxidative stress.