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العنوان
Cellular adhesion molecules in multiple sclerosis :
المؤلف
Salama, Hassan Hussein.
هيئة الاعداد
باحث / حسن حسين سلامه
مشرف / عزة المنجي المنجي محمد
مشرف / إقبال محمد أبوهاشم
مشرف / ماجدة علي البكري
مشرف / جنجيو زانج
الموضوع
Magnetic resonance imaging. Sclera - Diseases. Biomarkers and cell culture. Immunomodulator drugs. Multiple sclerosis.
تاريخ النشر
2003.
عدد الصفحات
499 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
علم الأعصاب السريري
تاريخ الإجازة
01/01/2002
مكان الإجازة
جامعة المنصورة - كلية الطب - Department of Neurology
الفهرس
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Abstract

The Current and future treatment strategies of MS disease Recent advances in our understanding of autoimmune mechanism involved in MS have prompted clinical trials in various forms to treat MS patients with some success. These clinical trials arc at various stages of development. Most of these experimental regimens arc still being evaluated for their treatment efficacy. These treatments vary in many aspects, and these therapies attack different elements in the disease processes. In general, they can be divided into two categories, (I) specific immunotherapy targeting putative myelin auto reactive T cells and a process related to their activation in vivo and (2) irnmunomodulatory drugs aimed to reduce or stabilize inflammatory reactions in the brain without targeting specific myelin autoreactive T cells ( Aharoni et al 1997 1998 2000 ) These drugs arc exemplified by beta-IFN and Copaxone. We are entering an interesting moment in medical history when many different experimental treatments are now available to patients with MS however, this also creates a dilemma for physicians to select an uppropriate treatment for their patients, and these opportunities enuse considered confusion among MS patients who attempt to choose between various clinical trial(s) and regirnen(s) that are available to them ( Tcitelbaum et al ., 1996: Rudiek et al 1997b).