الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
The present study was conducted on: 1Twenty subjects suffering from chronic renal failure (CRF) due to different intrinsic renal diseases. All of them were not yet receiving any traditional medical therapy nor performing dialysis (newly discovered uremic cases). None of the uremic patients had diabetes mellitus, liver disease or other primary associating diseases that affect directly this research.2Ten healthy persons selected from blood donors, patients? relatives and hospital workers were studied as a reference (control) group. They were matched in age and body mass index with the uremic patients. Blood samples were collected from every subject (patients and controls) after an overnight fast for measuring blood red cell indices by the use of cell counter, and serum creatinine, albumin, bilirubin, urea and uric acid by colorimetric methods. Also serum lipid profile was estimated by enzymatic methods. Apolipoprotein A1 and apolipoprotein B100 were assessed by radial immunodiffusion. Also serum tocopherol and plasma ascorbic acid were measured. Statistical analysis of the results was carried out using student?s ttest and Pearson?s correlation coefficient. This study demonstrates the existence of an antioxidant defect in CRF patients. This antioxidant defect is evidenced by presence of significant decrease of serum albumin, HDLC, ApoA1 and vitC levels in uremic patients while no significant difference in serum bilirubin and vitE were detected. This antioxidant defect in association with the known uremic dyslipidemia may contribute to the accelerated development of atherosclerosis in CRF patients. Extended studies on CRF patients are recommended considering the following.1Increasing the number of cases. 2Determining the induced enzymatic antioxidants. 3Determining intrinsic LDL antioxidants (vit E and Bcarotene) as well as intrinsic LDL modifications. 4follow up studies. 5 Bcarotene assay.