الفهرس 
Oxgyen affinity of haemoglobinOnly 14 pages are availabe for public view
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Abstract
Diabetes is a disorder in which the level of blood glucose is persistently raised above the normal range. The elevated levels of glucose binds with macromolecules including haemoglobin. It was found that binding of glucose with haemoglobin and other macromolecules can lead to over production of free radicals. Also, oxidative stress is greatly increased in diabetes due to prolonged exposure to hyperglycemia, over production of free radicals and/or decrease in the antioxidant defense resulting in the formation of oxidative stress. Among the sequellae of increased oxidative stress are lipid peroxidation, lipoprotein oxidation, longlive protein damage, and damage of gbsislet of pancreas. Therefore, the aim of the present study is to evaluate the haemoglobin affinity in diabetic children with type I diabetes. The correlation between the latter and the level of HbA1c and oxidative stress are also evaluated to thought more light on the mechanism of pathogenesis of diabetes. For these reasons, 86 children with insulin dependent diabetes mellitus (IDDM) and 22 healthy control children, The most important results of the present study are summarized as follows: 1 The mean blood glucose level was extremely significantly increased in diabetic patients. 2 The mean level of glycosylated haemoglobin (HbA1c) was extremely increased in all diabetic children than that of the healthy control group. 3 Red blood Hbaffinity of diabetic children was extremely significantly increased than that of the healthy control group. 4 The mean activity of superoxide dismutase (SOD) was decreased in serum of diabetic children than that of the healthy control group. On the other hand, the activity of this enzyme was increased in RBCs of such patients than the of the control one. 5 GSHPx and GSHR activities were increased compared with those of the control group. 6 The level of GSH was decreased. 7 MDA level was elevated in red blood cells in all groups of children with diabetes. from the results of these study, it was found that the elevated level of glucose is bound with many proteins of our body especially haemoglobin, forming what is called HbA1c. These type of binding lead to elevation of haemoglobin affinity leading to hypoxa which enhance diabetic complications.