الفهرس 
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Abstract
This prospective randomized blind study was conducted on forty patients subjected to elective prosthetic valve replacement. General anesthesia was induced by midazolam, fentanyl, and pipecuronium. Retrograde jugular bulb catheter was inserted. Patients were divided into two groups: Isoflurane group {n=20}: Anesthesia was maintained with isoflurane, fentanyl, and midazolam. Sevoflurane group {n=20}: Anesthesia was maintained with sevoflurane, fentanyl, and midazolam. Hemodynamic and jugular venous oxygen variables were recorded in both groups at certain intervals. Sevoflurane and isoflurane similarly have no significant differences on the cerebral oxygen extraction and cerebral blood flow equivalent, although sevoflurane reduced CMRO2 more than isoflurane during the normothermic periods of open heart surgery for elective prosthetic valve replacement. This advantage could be beneficial during prolonged anesthesia and surgery under normothermia particularly, neurosurgical procedures.