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العنوان
Evaluation of some prognostic factors in childhood acute lymphoblastic leukaemia /
المؤلف
Badran, Heba El­Said Abd El­Wahhab.
هيئة الاعداد
باحث / Heba El­Said Abdel­Wahhab Badran
مشرف / Samy Marouf Mohammed
مشرف / Nabil Mahmoud Abd El­Razik
مشرف / Manal Ibrahim Fouda
الموضوع
Lymphoblastic leukemia. Lymphoblastic leukemia in children.
تاريخ النشر
2005.
عدد الصفحات
123 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
أمراض الدم
تاريخ الإجازة
1/1/2005
مكان الإجازة
جامعة المنصورة - كلية الطب - Clinical Pathology Department
الفهرس
Only 14 pages are availabe for public view

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from 130

Abstract

The Value of some clinical and laboratory characteristics for the prognosis of acutely mphoblastic leukaemia (ALL)in a group of 26 children with newly diagnosed ALL was evaluated. Single parameter flow cytometric detection of DNA content ,%of cells in different phases of cell cycle and P­glycoprotein expression were done for all patients and they were followed up for six months. The results were statistically analyzed. DNA hyperploidy as detected by DNA flow cytometry using propedium iodide staining was correlated with complete remission(Pvalue =0.045). Nither % S phase or P­glycoprotein expression had impact on prognosis of our ALL patients. Among different prognostic factors evaluated, only DNA ploidy was the statistically significant parameter predicting complete remission in children with ALL.