الفهرس 
Introduction and aim of work
Determinants of obesity and overweightOnly 14 pages are availabe for public view
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Abstract
The aim of the present work is to evaluate IL6 serum level in obese subjects. Also, to study the relation of IL6 serum level to different clinical and laboratory parameters before and after weight reduction program .The study included 71 obese patients 47 females and 24 males) with a mean age 32.31 years. They were collected from Rheumatology and Rehabilitation Outpatient Clinic in Mansoura University Hospital. The obese individuals were compared with 20 apparently healthy control volunteers, age and sex matched. IL6 is produced by cells of the immune system and adipocytes and this may provide the link between inflammation and obesity, diabetes, hypertension and CAD. IL6 is the major determinant of production of the acutephasereactant CRP, by the liver. Obesity, diabetes, hypertension and CAD are considered as inflammatory conditions as evidenced by the elevated proinflammatory markers (we tested IL6 and CRP in this study. Clinicians should be aware that obese individuals are at substantially increased risk of having an elevated IL6 and CRP; and this study suggested that these markers remain independently predictive of cardiovascular disease and diabetes mellitus among obese individuals. The associations of CRP and IL6 in obesity associated conditions are additive, such that the highest CRP and IL6 levels were observed among heavier subjects who were both diabetic and suffering of CAD than heavier patient who is diabetic only or with CAD only. Weight loss in obese subjects has been shown to decrease IL6 and CRP levels. Weight loss is expected to result in reduced cardiovascular risk associated with CRP. Since the majority of patients with diabetes and cardiovascular disease are overweight, this is possibly one of the mechanisms by which diabetic patients and CAD patients have an increased production of these two markers; IL6 and CRP. It has been reported that CRP and IL6 correlate with BMI. Increased concentrations of CRP and IL6 may affect the development of CAD, creating a more severe lesion.