الفهرس 
Introduction
Aim of the workOnly 14 pages are availabe for public view
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Abstract
The present work was designed as epidemiological and physiological study to prevent a general feature on liver disease and its association to viral hepatic infection in Damietta governorate. The link was studied between the liver function tests and the stage of liver disease, as well as, the correlation was also conducted between the level of serum alphafetoprotein and the progressive of the disease. Each one of the patients or the control cases was subjected to ultrasongraphy (US) examination and reviewed for epidemiological data, including age, sex, and medical disease.Tests were conducted for serum antHAV, HBV and HCV antibodies for every person. The panel of liver function tests was conducted including determination of serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), albumin, total protein, cholesterol, triglycerides, and bilirubin. The concentration of alphafetoprotein was also determined for all studied cases. Epidemiological data showed that : of 79 patients with liver disease; 10 cases were HAVcarriers and the rest (69) cases were HCVcarriers, the viral hepatic infection was closely related to the gender, and age. Based on US and medical diagnosis, HCVcarriers were allocated into 5 groups; 27/69 active hepatitis, 22/69 nonactive hepatitis, 2/69 fatty liver, 4/69 fibrosis, and 17/69 cirrhosis.Biochemical data for HAVCarriers showed that serum ALT and AST activity were higher in all of the than that of normal levels about 10folds or more. Mostly, serum activity of ALP was also higher. All HAVcarriers had elevated levels of serum bilirubin concentration at 2 to 3folds than that of the normal. No valuable differences were observed in other tested parameters. No relation was found between HAVinfection and serum alphafetoprotein.While in HCVCarriers, the mean level of serum ALT, AST, and ALP was significantly higher than that of the control cases, lowered levels of serum albumin were obtained in HCVcarriers at prevalence of 26.09% as well as the mean level of serum cholesterol and triglycerides was significantly higher The mean level of serum alphafetoprotein was significantly higher in HCVcarriers than that of the normal. In general, there was a correlation between the serum level of alphafetoprotein and albumin, globulin, cholesterol and triglycerides, but not with serum enzymes and bilirubin.