الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Cytokines play an important role in the pathogenesis of lymphomas. An elevated serum or tissue level of cytokines can contribute to the clinical and histopathological alterations in NHL. The aim of the present study is to assess serum levels of IL-10 and IL-6 in NHL patients in Mansoura Hospitals and to correlate these levels with other known prognostic factors and patients outcome The study comprised 40 patients with newly diagnosed NHL and 20 healthy volunteers with matched age and sex were taken as a control. All patients received treatment for NHL and were followed-up in an out patient department and observed over 18 months or until death. 11 patients died during the follow up time. All patients (at diagnosis) and healthy controls were subjected to some laboratory investigations as CBC, serum LDH, liver functions tests (ALT, AST, Albumin and Bilirubin). Serum levels of IL-10 and IL-6 using ELISA technique were carried out for patients (at diagnosis and at remission) and healthy controls. Our studies showed that IL-10 and IL-6 levels were significantly elevated in the NHL patients compared to control group. Also there was a highly significant increase in IL-10 and IL-6 at diagnosis than at remission.A positive correlation was found between serum IL-6 levels and the presence of B symptoms, where NHL patients with B symptoms showed a significant increase in serum IL-6 levels than in patients without B symptoms. The comparison between non-survived and survived NHL patients show a highly significant increase in serum IL-10 and IL-6 levels in non-survived patients compared to survived patients at diagnosis. from this study we conclude that elevated serum IL-10 and IL-6 levels in NHL patients, were associated with bad patients outcome, independently of other established prognostic factors. The generalization of the use of biological markers may help in the better assessment of tumor prognosis and follow up of treatment.