الفهرس 
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Abstract
Aim of work : This study was planned to evaluate the neuromuscular blocking profile and haemodynamic characteristics of rocuronium in patients suffering from hepatic cirrhosis. Patients: Fourty patients were included in this study, allocated equally into two groups, noncirrhotic group and cirrhotic group submitted for intr abdominal elective surgeries. Methods: Anesthesia was induced with thiopentone sodium until loss of eye lash reflex followed by rocuronium (o.6 mg/kg) to facilitate endotracheal intubation and was maintained by N2O: O2 (2:1) and isoflurane (0.5-1%) with 0.12 mg/kg of rocuronium as maintenance relaxation doses. Neuromuscular monitoring was accomplished by relaxography (Datex) to evaluate the neuromuscular blocking effect of rocuronium. The device displayed T1 and TOF ratios. The onset of action of rocuronium was measured from administration of drug till suppression of T1 to 10% and TOF ratio to approximately 0%, where endotracheal intubation was performed. The duration of action was also measured from the time of administration till recovery of T1 to 25%. Results: This study revealed that, the onset time showed no significant difference between both groups. The duration of action of rocuronium was significantly longer in cirrhotic group with successive maintenance doses. The recovery times and total dose requirements showed no significant difference between the two groups of patients. Heart rate, blood pressure did not show significant variation in both groups. Conclusion: from this study, it may be concluded that the dosing of rocuronium in patients with liver cirrhosis should be guided by careful monitoring of neuromuscular function.