الفهرس 
Introduction
phosphoracetyl L aspartic acid (PALA) and BrequinarOnly 14 pages are availabe for public view
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Abstract
The protective effects of glutathione (GSH) and granulocyte colony stimulating factor (GCSF) on myelosuppression induced by 5fluorouracil (5FU) were compared in female mice. Animals were allocated to seven groups , the first three were 10/group while the last four were 20/group and were divided into 2 subgroups each. Groups 4a and 4b received 5 FU in a single dose of 160mg/kg by intraperitoneal route Groups 5a and 5b received 5FU and GSH in a daily dose of 800mg/kg for 1 week by intraperitoneal route. Groups 6a and 6b received 5FU and GCSF in a daily dose of 250 ug/kg subcutaneously for 1 week.Groups 7a and 7b received 5FU, GSH and GCSF. The (a) groups were killed after 1 day of 5FU while (b) groups were killed after 1 week of 5FU. In groups 5 and 6 protection was demonstrated regarding neutropenia, bone marrow cytology and histopathology, while groups 7a and 7b revealed no protection at all. Therefore, GSH and GCSF have preventive effects against 5FU induced haemopoietic toxicity, while combination between them showed no protection.