الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
Clomiphene citrate is a nonsteroidal fertility drug taken orally for the purpose of inducing ovulation It is often a first line of treatment in young women who may be anovulatory or oligoovulatory & dysovulatory. In the present study, administration of daily oral doses of 0.5 mg/kg. body weight to pregnant mothers of albino mice from the 6th to 11th day of gestation reproduced hazardous effects on hepatic, renal and myocardial tissues & lung tissues of mothers at parturition. On the other hand treated pregnant mothers with folic acid besides clomiphenetreatment revealed marked amelioration of the histological picture of the investigated organs in mothers and their newborn. The present study showed that clomiphene<U+2013>treatment during the progress of pregnancy increased the average rates of both aborted mothers and neonatal mortality.The rate of morphological abnormalities of delivered newborn of clomiphenetreated mothers appeared markedly increased. The Body weight, size and crownrump length were highly affected. Ossification of different parts of axial and appendicular regions were retarded. The incidence of missing ossified bones of newly born were comparatively reduced in those of mothers received clomiphenetreatment comparing with the other experimental groups. On the other hand, experimental groups received folic acidtreatment in combination with clomiphene showed low rates of malformation defects as well as their average growth of weight, size and crown rumplength as well as ossification of axial and appendicular skeleton were observed at least almost nearly the normal pattern. Finally, the author concluded that treatment with either clomiphene exerted its drastic effect as a result of its estrogenic formation. Beside, to avoid its hazardous effects, folic acid should be administered in order to provide us with a source of antioxidants. These give us some supports to cells of our body organs as well as to developing embryos against clomiphene fetotoxicity