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العنوان
Screening for some lymphoproliferative clonal markers following renal transplantation /
المؤلف
Gabr, Ahmad Shawki Mohammad Hassan.
هيئة الاعداد
باحث / أحمد شوقى محمد حسن جبر
مشرف / فرحة عبدالعزيز الشناوي
مشرف / إلهام رجب عبدالسميع
الموضوع
Lymphoproliferative Disorders. Flow cytometry. Renal Transplantation. Kappa. Lambda. Lymphoproliferative disorders - Molecular aspects. Lymphoproliferative disorders - Immunological aspects.
تاريخ النشر
2004.
عدد الصفحات
96 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الطب
تاريخ الإجازة
01/01/2004
مكان الإجازة
جامعة المنصورة - كلية الطب - Clinical Pathology Department
الفهرس
Only 14 pages are availabe for public view

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from 122

Abstract

Post­renal transplant lymphoproliferative disorders (PTLDs) is a well known category among all the other lymphoproliferative disorders. The cause of this complication is mainly due to long term immunosuppression, and infection particularly by Epstein­Barr virus (EBV). Early recognition of clonal changes is very important for early therapeutic intervention as most of these changes are polyclonal. Yet the transition to oligo­ and subsequent monoclonal is important for follow up with other investigations to reach the proper diagnosis. So, the objective of this study was to clarify whether post­renal transplant lymphoproliferative disorders are polyclonal (benign), or monoclonal (malignant) B­cell proliferation. The statistical analysis of our results showed the following: 1­ There is a high statistically significant increase in CD19 in patients when compared to the healthy group. 2­ There is a high statistically significant increase in CD20 in patients when compared to the healthy group. 3­ There is a statistically significant difference in Kappa/Lambda ratio in patients when compared to both the healthy group and the lymphoma patients. And we concluded that some of these post­ renal transplant patients had abnormal hematological findings in the form of oligoclonality, which may lead to subsequent hematological malignancies; PTLDs.