الفهرس 
INTRODUCTION AND AIM OF THE WORKOnly 14 pages are availabe for public view
 |  | from | 114 |  |  |
| | | from | 114 | | |
Abstract
The majority of normal cell types are constrained by adhesion to each other and to the extra cellular matrix (ECM). Normal cells are not static, they are able to move in a regulated fashion by modulating their adhesion in a controlled way, for example; neural crest migration, trophoblast implantation and angiogenesis which is of particular importance in cancer because tumours can not grow extensively without blood supply. Aim of work: Determination of serum level of matrix metalloproteinase9 (MMP9) in a trial to find its possible role in the clinical outcome and prognosis of patients with lymphoma. Methods: This study was conducted on 24 patients of newly diagnosed lymphoma (8 patients had HD and 16 had NHL), all of them were males and there age group ranged from 17 to70 years. And 10 apparently healthy male cases, there age ranged from 26t 56 years. All Patients and control were subjected to the following clinical and laboratory studies: Detailed history taking, Complete clinical examinations, routine Laboratory investigations(CBC, ESR, LDH, liver function tests etc), Bone marrow aspiration and examination for staging and lymph nodes biopsy, Radiological investigations and assay of matrix MMP9 in plasma of patients & control employing the quantitative sandwich enzyme immunoassay technique ELISA. Results: As regard clinical findings, 11 patients had generalized lymphadenopathy (9 of them were NHL and 2 were HD), 13 patients had localised lymphadenopathy (7 of them were NHL and 6 were HD), 22 patients had B symptoms (14 of them were NHL and 8 were HD), 6 patients had hepatosplenic affection (all of them were NHL), 10 patients were in early stages (4 of them were NHL and 4 were HD) and 14 patients were in late stages (12 of them were NHL and 2 were HD) all these findings have improved after treatment. As regard MMP9, the patients had elevated MMP9. And after treatment, its level has decreased. Conclusion: There was significant higher levels of MMP9 in lymphoma patients than in normal persons. There were significant correlations between MMP9 and some of the bad prognostic factors of lymphoma: generalized lymphadenopathy, hepatosplenomegaly, late stage, anemia, elevated ESR and elevated LDH. These findings have disappeared after treatment (chemotherapy and radiotherapy). This may reflect the role of MMP9 in lymphoma prognosis.