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Abstract Pigmentation involving 1 to 2% of the world? s population, affecting males and females and the various races equally. It is characterized histologically by the absence or marked reduction in the melanocytes in the basal epidermal layer and clinically by the presence of depigmented lesions of variable shapes and sizes. It represents a particular aesthetic problem in dark skinned people. The precise cause of the loss of epidermal melanocytes and development of vitiligo is unknown. There are several hypothesis for the pathogenesis of vitiligo including: Genetic, neural, autoimmune, autocytotoxic and recently, melanocyte growth factor deficiency and melanocytorrhagy theories. Vitiligo can be classified into :Localized, generalized and mixed.Localized vitiligo includes focal and segmental types, generalized vitiligo includes acrofacial, vulgaris, universalis types and mixed vitiligo which could present for example by acrofacial and segmental types. Medical therapies for vitiligo include:Topical and systemic corticosteroids, topical immunomodulators, topical vitamin D derivatives, topical or systemic photochemotherapy (psoralen + UVA or khellin+UVA) and phototherapy in the form of:NBUVB (R+ (Btopical pseudocatalase ,microphototherapy and 308 nm excimer laser. |