الفهرس 
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Abstract
The present study is undertaken to induce a picture similar to that of fulminant viral hepatitis by injecting bacterial lipopolysaccharide produced by Escherichia coli in Dgalactosamine sensitized mice. Then we correlated the structural changes in the liver with the changes in the liver function at different periods. Serum transaminases were markedly increased till five days after injection then gradually decreased till it reached the normal values fifteen days after injection. The liver tissue showed variable degrees of necrosis, starting two hours after injection as single cell necrosis and reaching the maximum effect one and five days after injection in the form of massive focal necrosis. This is followed by gradual regeneration. By using electron microscopy hepatocytes showed pyknotic nuclei, proliferated and fragmented rough endoplasmic reticulum, enlarged and deformed mitochondria, proliferated lysosomes and massive fatty degeneration. Space of Disse and bile canaliculi were markedly dilated with partial loss of the microvilli projecting from the surface of hepatocytes. Although the liver enzymes became normal fifteen days after injection, the liver tissue still showing minimal degree of affection in the form of microvesicular steatosis.