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Abstract Brown spot caused by Bipolaris oryzae is one of the important rice diseases in the world including Egypt. Widespread, reported in all rice growing countries of Asia, America and Africa. It can be a serious disease causing a considerable yield loss. It can cause 1058% seedling mortality; it also affects the quality and the number of grains per panicle and reduces the kernel weight according to the disease severity. Chemical control may be available to reduce the effects of brown spot disease on young plants effectively and extensively, but field application of these chemicals may not always be desirable. So that, the present work aimed to replacement the undesirable and unsafe chemical control by another effective, inexpensive and safe options for rice brown spot disease control. Two ways were suggested here to overcome this problem in this study, the biological control (Trichoderma harzianum) and the induction of systemic acquired resistance in the plant (benzoic acid and salicylic acid). The results obtained concluded that application of biological control by T. harzianum at 1x108 spores/ml or application of benzoic acid at 20 mM play an important role in the control of rice brown spot disease caused by B. oryzae. |