الفهرس 
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Abstract
Studied the disturbed anatomical construction of the large intestine in chsprung’s disease (congenital mega colon). Thirty suspected specimens of human colons e taken from inpatient wards of Gastroententrology Centre (G.E.C) and Pediatric Unit (P.S.U) of Mansura University Hospitals. (M.U.H). the ages of these patients e ranging from seven months up to four years old. Twenty patients of them were diagnosed clinically, radiologically and pathologically as Hirschsprung’s disease containing ten patients were free and considered as control cases. Specimens were taken from proximal dilated segments and the distal contracted of patients suffering from Hirschsprung’s disease as well as from the control cases. specimen was fixed, dehydrated, embedded in paraffin, sectioned serially at 6-8 crones and stained by haematoxyllin and eosin, periodic and Schiff, alcian blue, and Glee’s Sliver stains. These stains compared the normal histology of control cases of the diseased cases. Acetyl cholinesterase activity in the control and diseased cases was demonstrated using paraffin sections or cryostat cut sections then incubated in a medium containing The catecholarnines containing fibers in proximal ganglionic, distal ganglionic and troll specimens were detected using fresh frozen sections and incubated in a medium tainting glyoxalin acid. from data obtained from this work, the mucosa of control, ganglionic and ganglionic showed normal histological pattern showed normal histological pattern, containing die sulphomucin and intact cholinergic nerve fibers. The submucosa of the control and ganglionic segments were nearly similar in structure and contained submucosal nerve uses, blood vessels and lymphatics. While in the ganglionic segments, the submucosa significantly thickened and no ganglion nerve cells could be detected in addition to sense of hugely hypertrophied nerve trunks.