الفهرس 
Introduction & Aim of the Work
Pathogenesis of HCCOnly 14 pages are availabe for public view
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Abstract
Introduction: It is well established that tumor growth and the development of local and or distant metastasis is angiogenesis dependent. VEGF plays a fundamental role in regulation of normal and abnormal angiogenesis. Aim of work: This study was designed to evaluate the prognostic value of VEGF expression in hepatocellular carcinoma. Patients and methods: The study included 40 patients (30 males and 10 females) with hepatocellular carcinoma where, VEGF expression was detected by immuno-peroxidase technique using polyclonal anti-VEGF antibody Results: 23 cases showed high VEGF expression, 3 cases showed moderate expression and 14 cases showed negative expression. There was significant relation between VEGF expression and tumor size, enhancement in arterial phase of Tri-phasic CT scan of the abdomen, tumor differentiation, capsular invasion and vascular invasion. There was significant relation between VEGF expression and development of local and or distant metastasis and also with DFS and OS. Conclusions: This study suggests that patient with high VEGF expression have biologically aggressive disease and VEGF expression is a significant predictor for DFS and OS. VEGF can be used as both a target of therapy and a potentially predictive marker for using novel adjuvant therapeutic strategies based on inhibition of angiogenesis.