الفهرس 
Introduction and Aim of the WorkOnly 14 pages are availabe for public view
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Abstract
BACKGROUND: A high prevalence of both diabetes and impaired fasting glucose has been reported in HCV- infected patients in comparison with other liver diseases. The exact mechanism for this high incidence is still obscure. In the current study the prevalence of insulin resistance in non diabetic HCV patients and its association to ferritin. Also, the value of glycosylated hemoglobin in patients with chronic liver disease was examined. METHODS: Between February 2006 and March 2007, 50 patients with hepatitis C virus infection whether cirrhotic or non cirrhotic were collected. Routine lab., viral markers, PCR for HCV infected patients, serum ferritin, HOMA-IR, HOMA-B, liver biopsy ,blood glycosylated hemoglobin and pelviabdominal ultrasound were done. RESULTS: Insulin resistance was found in the non cirrhotic HCV patients when compared to control (P <0.001). There was significant positive correlation between insulin resistance and serum ferritin level (P <0.001).Also, there was significant positive correlation between insulin resistance and body mass index(P=0.046).Glycosylated was below the non diabetic reference range in 44% of the non cirrhotic group in comparison to 25% in the cirrhotic group.Also,it was negatively correlated with reticulocytic count in both groups( P<0.001 )CONCLUSION: Insulin resistance is present in early stages of chronic hepatitis C.Insulin resistance seems to be related to high serum ferritin level. Glycosylated hemoglobin should be used with caution in chronic liver disease and in context with liver function complete blood picture and reticulocytic count