الفهرس | Only 14 pages are availabe for public view |
Abstract Respiratory disorders are major causes of mortality and morbidity in neonates. Genetic factors appear to influence the development of various neonatal respiratory disorders such as respiratory distress syndrome (RDS), transient tachypnea of the newborn (TTN), bronchopulmonary dysplasia (BPD), cystic fibrosis, congenital alveolar proteinosis and primary ciliary dyskinesia (PCD). The availability of clinically useful genetic markers and tools that allow detection of variability in the structure of the genes regulating respiratory function in neonates, was helpful to confirm genetic basis for neonatal respiratory disorders. Genomic DNA isolated from umbilical cord blood specimen were subjected to polymerase chain reaction (PCR) amplification for detection of gene polymorphism affecting respiratory products genes. The study of genetic aspects of neonatal respiratory disorders, helps development of rational strategy for management of neonatal respiratory disorders and permits more accurate genetic counseling of families whose infants are at risk of developing respiratory disorders during neonatal period. |