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العنوان
Genetic aspects of neonatal respiratory disorders /
المؤلف
Awad, Mohamed Awad Abd El-Karim.
هيئة الاعداد
باحث / محمد عوض عبدالكريم عوض
مشرف / محمد عبدالرحمن شقير
مشرف / هشام السيد عبدالهادى
مناقش / مجدى محمد زيدان
مناقش / علي محمد ابوزيد
الموضوع
Surfactant. Genetic aspects. Cystic Fibrosis.
تاريخ النشر
2007.
عدد الصفحات
227 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
طب الأطفال ، الفترة المحيطة بالولادة وصحة الطفل
تاريخ الإجازة
1/1/2007
مكان الإجازة
جامعة المنصورة - كلية الطب - Department of pediatrics
الفهرس
Only 14 pages are availabe for public view

from 240

from 240

Abstract

Respiratory disorders are major causes of mortality and morbidity in neonates. Genetic factors appear to influence the development of various neonatal respiratory disorders such as respiratory distress syndrome (RDS), transient tachypnea of the newborn (TTN), bronchopulmonary dysplasia (BPD), cystic fibrosis, congenital alveolar proteinosis and primary ciliary dyskinesia (PCD). The availability of clinically useful genetic markers and tools that allow detection of variability in the structure of the genes regulating respiratory function in neonates, was helpful to confirm genetic basis for neonatal respiratory disorders. Genomic DNA isolated from umbilical cord blood specimen were subjected to polymerase chain reaction (PCR) amplification for detection of gene polymorphism affecting respiratory products genes. The study of genetic aspects of neonatal respiratory disorders, helps development of rational strategy for management of neonatal respiratory disorders and permits more accurate genetic counseling of families whose infants are at risk of developing respiratory disorders during neonatal period.