الفهرس 
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Abstract
This study was performed in Internal Medicine & Infectious and Fish Diseases Dept. Fac.Of Vet. Medicine, Mansoura University:- This study was carried out on 1200 neonatal calves (1-30 days of age) in three different farms in three different governorates (El-Dakahilia, Domiatta and El-Behara). The clinical examination of these calves revealed that there were 200 calves suffered from different degrees of diarrhea, dehydration; The calves were classified according to their ages into 4 groups: fecal swabs and fecal samples were taken from diseased calves, Trials of viral isolation from rectal swabs on MDBK cell culture revealed that Rota viruses was isolated from 38 samples out of 200 samples (19%). Bacteria isolation of revealed that E- coli was isolated from 46 samples out of 200 samples examined (23 %) and Salmonella spp. were isolated from 11 samples out of 200 samples examined (5.5 %) and one sample was found infected with mixed Salmonella The typing of isolated bacteria revealed that, among 46 isolate of E-coli, E-coli K99 antigen were detected serologically in 5 samples by (10.9 %) and E-coli antigens O119:B14, O26:B7, O111:B4 and O55:B5 were detected in 3, 8, 10 and 12 isolates respectively and 8 isolates were untyped. in 11 Salmonella spp. Isolates, 6 isolates were identified serologically as Salmonella typhimurum and 3 isolate Salmonella enteriditis and 2 isolates were un typed. Cryptosporidium were detection of Cryptosporidium parvum oocysts by floatation and staining methods by modified Zeil neelson stain revealed that 60 samples of 200 examined fecal samples (30%) were found infected with Cryptosporidium parvum oocyst. In this study two commercial available vaccines were used as a trail to control neonatal diarrhea (Entero- 3 and Scour Guard vaccines) titer of antibody were measured in serum of vaccinated and control dams and born calves.