الفهرس 
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Abstract
The aim of the work: to investigate the relationship between diabetic retinopathy and MCP-1 level in the aqueous humor and serum, Also, the association between DR and the serum levels of nitrite and CRP. Material & Methods : This study was conducted on 44 subjects of both sex (18 males and 26 females), with mean age 61 ? 6.1 years and they were classified into three groups: 1. Non proliferative diabetic retinopathy group: comprised 15 patients (6 males and 9 females). 2. Proliferative diabetic retinopathy group: comprised 15 patients (8 males and 7 females). 3. Control group: comprised 14 subjects (4 males and 10 females). Aqueous and serum samples were collected from all subjects. Aqueous humor samples were aspirated and analyzed for MCP-1 by ELISA. Fasting blood samples were collected and analyzed for serum MCP-1 by ELISA, serum CRP by turbidimetry and serum nitrite by colorimetry using Griess reaction, HbA1c, fasting blood glucose and lipid profile were also estimated. Results : There was a statistically significant increase in the aqueous MCP-1 level in patients with diabetic retinopathy when compared with control group. There was nonsignificant difference in aqueous MCP-1 level in between both groups of diabetic retinopathy. There was nonsignificant difference in serum MCP-1 between patients with diabetic retinopathy and control group. Aqueous levels of MCP-1 were higher than serum MCP-1 but with no significant correlation. Conclusion: MCP-1 seems to have a strong relation to the pathogenesis of diabetic retinopathy. MCP-1 in the aqueous humor can be used as a marker is diagnostic for the presence of the disease rather than its severity.