الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Considering the several theories and suggestions enlightening the relevance and design of novel compounds that are used as antiviral and antioxidant active agents, assisted by a comprehensive literature survey on the importance of benzothiazole based drugs as unique therapy for combating viral infections and free radicals, the synthesis of novel series of compounds that carry the main structural features contributing to antiviral and antioxidant activity was promoted, aiming to attain more potent and less toxic drugs.
In the present investigation, new series of N-substituted-2,4-diamino-6-(benzothiazolyl-2-thiomethyl)-s-triazines, N-substituted-2,4-diamino-6-[(2,3-dihydro-2-iminothiazol-3-yl)methyl]-s-triazines and 6-(substituted amino)-2-methylbenzothiazoles were synthesized
In order to obtain the target compounds, different chemical pathways were adopted and found to be successful. In the present study, twenty two novel compounds that are not mentioned in the available literature were synthesized. New intermediates were also synthesized guided by the published literature. The formation and purity of the newly synthesized compounds were checked by TLC, and their structures were elucidated through elemental microanalyses, IR, 1H-NMR and mass spectroscopy.
Twelve representative compounds were subjected to antiviral and cytotoxic screening, using plaque-reduction assay and aphidicolin as a reference drug. The results showed that all tested compounds exhibited some degree of cytotoxicity and only two compounds showed promising antiviral activity.
Eleven compounds of the newly synthesized ones were subjected for preliminary in vitro screening for antioxidant activity using ABTS antioxidant assay and ascorbic acid as a reference drug. The result revealed that many compounds showed different degree of antioxidant activity.