الفهرس 
Bronchial asthmaOnly 14 pages are availabe for public view
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Abstract
monocyte chemotactic protein-4 and nitric oxide in patients with acute exacerbated bronchial asthma as well as patients with chronic-stable bronchial asthma and to investigate their relations with the severity of asthma. Methods:The subjects included in this study were classified into: Group l: Comprised 20 patients with acute exacerbation of bronchial asthma. Group ll: Comprised 20 patients with chronic stable bronchial asthma . Group lll: 12 healthy volunteers were taken as a control group. All patients and control groups were subjected to pulmonary function tests and skin prick test to common allergens and blood easinophilic % The serum levels of eosinophilic cationic protein, monocyte chemotactic protein-4 and nitrite were estimated. Results: There was a significant increase of serum ECP level in patients with acute sever bronchial asthma as well as chronic stable bronchial asthma when compared with the control group, also There was a significant increase in serum ECP in atopic patients when compared with non atopic patients. There was a significant increase in serum MCP-4 concentration in patients with acute sever bronchial asthma and patients with chronic stable bronchial asthma when compared with healthy controls and there is a significant increase of MCP-4 concentration in acute sever bronchial asthma patients when compared with patients with chronic stable bronchial asthma. Also there was a highly significant increase of serum nitrite concentration in patients with acute sever bronchial asthma and patients with chronic stable bronchial when compared with control group Conclusion: from this study it could be conclude that, Asthma is acompanied by increased level of eosinophil and eosinophilic products ECP which is better inflammatory marker than eosinophil count in blood samples as it reflect the degree of activation of eosinophil. The MCP-4 is a systemically expressed biomarker that independently predicts susceptibility to asthma and is directly associated with exacerbations. This study demonestrated increased levels of nitric oxide metabolites in bronchial asthma patients which responsible for the increased airway hyperreactivity in asthma