الفهرس 
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Abstract
This study was designed to evaluate the efficacy of ciprofloxacin in treatment of collibacilosis in broilers, the toxic effect of this drug on blood and body organs and the interaction between the drug and iron outcome. Three hundred Hubbard broiler chicks were divided into ten groups each group contain 30 birds. Five of them were experimentally infected by E.coli strain O:78 at the 14th day of age and treated orally in drinking water with ciprofloxacin 50mg/L, 100mg/L, ciprofloxacin plus iron, iron treated group only and one group left untreated. The others were treated with ciprofloxacin 50mg/L, 100mg/L, ciprofloxacin plus iron, iron only and a control group that uninfected untreated. Chicks were fed balanced ration and given water ad libitum. Treatment schedule began after the clinical signs appeared in the infected group and continued for five consecutive days. Blood samples were collected for hematological examination & serum chemistry from all examined groups 1, 3, 5, 7 and 14 day post-treatment, then chicken were slaughtered and specimen from liver, kidney, spleen, intestine, heart and lung were collected for histopathological studies. The result revealed that co-administration of ciprofloxacin as a quinolone with iron as a cation prevented the action of the drug.