الفهرس 
Preface
ApparatusOnly 14 pages are availabe for public view
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Abstract
This thesis describes the application of stability-indicating methods for the determination of certain nitroaceutical compounds, vitamin A and ascorbic acid in pure form and in dosage forms. The thesis includes four main
arts.
Part I
include two chapter. Chapter A
deals with the 1PLC determination of some important nitro-compounds namely, furazolidone,nitrofurazone, nitrofurantoin, niridazole and nifuroxime in the presence of their degradation products. Degradation of these nitro-compounds was accomplished by exposing an aquous solution of these drugs to indirect sun¬light at room temperature. The peak height was found to be linear to the concentration of the analyte. The different experimental parameters were carefully studied. The mean percentage recoveries of authentic samples of furazolidone, nitrofurazone, nitrofurantoin, niridazole and nifuroxime ranges from 99.93±1.61%, 99 . 97±1 . 44%, 99.94±1 .34%, 99.94 + 1 .02% and 1G0.G0±1.151, respectively. Statistical comparison between the proposed and the compendial methods indicates that there is no significant difference between the recover¬ies of both methods with respect to accuracy and precision. The proposed method was successfully applied in the analysis of these nitrocompounds in some dosage forms.
Chapter B describes the simultaneous HPLC determina¬tion of furazolidone and nifuroxime. The proposed HPLC method mentioned in chapter I was further applied in the [analysis of this mixture. The percentage recoveries of au¬thentic samples of the two compounds amounts to 99.99±0.53$ for furazolidone and 99.99±U.36% for nifuroxime . Supposi¬tories containing the two drugs in the medicinally recom¬mended ratio were analysed using the proposed method. The mean percentage recoveries were found to be 99.93±0.71/and 99.92±o.57/ for furazolidone and nifuroxime, respectively.
Part II includes two chapters, Chapter A deals with the HPLC determination of vitamin A in presence of its deg¬radation products. Degradation of vitamin A was accompli¬shed by heating of an aqueous alcoholic solution of the drug. The peak height was found to linear to the concentr¬ation of the analyte in the concentration range of vitamin A. The mean percentage recovery of authentic sample was 100.043± 1.23% Statistical analysis showed no significant difference in precision and accuracy of the proposed and official methods.
Chapter B describes a stability indicating spectropho-tometric determination of vitamin A in the presence of its degradation products via charge transfer complexes. Degra¬dation of vitamin A was accomplished by heating of an aqueous alcoholic solution of the drug. The first method
is based
on addition of iodine to vitamine A followed by the measure¬ment of the absorbance at 241 nm. The mean percentage reco¬very of authentic samples amounts to 99 -99±1 -13%.
The second
method is is based on the addition 7,7,8,8-tetracyanoquinodimethane to vitamin A followed by the measu¬rement of the absorbance at 843 nm. The mean percentage recovery of authentic sample amount to 1 U0 . 009± 1 . 31 /^phar¬maceutical preparations containing vitamin A were analysed using these two proposed methods and the official methods. Statistical analysis showed no significant difference in precision and accuracy of three methods
Part III
describes stability indicating spectropho-tometric determination of ascorbic acid using two different methods. Degradation of these ascorbic acid was accomplished by heating an aqueous solution of these drug at 85°C. The first method is based on the application of difference spectrophotometric technique using cupper sulphate as oxidi¬zing agent. The difference in the absorbance before and .. after oxidation was found to be linear to the concentration of ascorbic acid. The mean percentage recovery of authentic sample amounts to 99.7+0.40/ .
The second method is based on the formation of a red colour after the addition of 2,2-dipyridyl and ferric ammon¬ium sulphate followed by measurement the absorbance of red colour at 5’^G nm. The mean percentage recovery of authentic
sample amounts to 100.05±1.32 % pharmaceutical preparations containing as corbie acid were analysed using the two proposed methods and the official methods. Statistical analysis showed no significant difference between the three methods.
Part IV in this part reognts and apparatus as well as detailed descriptions of the procedures adopted.