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Abstract Polymeric films have been widely and successfully employed in many pharmaceutical, industrial and medicinal fields. Selection of the best film for any particular use is a matter of matching its properties against the end use performance required. These properties are concerned with swelling properties, moisture permeation, and mechanical properties of the film. With the rapid increase in the use of natural biodegradable polymers, chitosan with its properties of chemical modifications has gained a considerable attention. The abundance of chitosan in nature and its safe toxicological profiles have prompted researchers worldwide to investigate its potential pharmaceutical and biological applications. In spite of the well-known film forming properties of chitosan, only a few studies have been performed on the usefulness of chitosan films as drug delivery system. Chitosan is available in different grades varymg m molecular weight, viscosity, and degree of deacetylation (%DD) which are ranged from 40-98%. Commercially available chitosan, is not well characterized especially regarding molecular weight and degree of deacetylation therefore, it must be necessary to continue investigating the physicochemical characteristics of chitosan films for the In vitro as well as In vivo performance based on chitosan. The main concern of the work in this thesis is to prepare protective films of chitosan by the casting technique using acetic acid as a casting solvent. |