الفهرس 
Introduction and aim of workOnly 14 pages are availabe for public view
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Abstract
Psoriasis (PSO) is a chronic, genetically determined inflammatory skin disease affecting approximately 2% of the northern population. Beside allergic contact dermatitis and atopic dermatitis, PSO is the most common chronic skin disease.
This work is organized to investigate the role of cytokines associated with individual genetic make up and that is represented in their cytokine gene polymorphisms on psoriasis susceptibility and/or severity.
This study revealed that certain cytokine gene polymorphisms were presented in a significant higher frequency among Psoriasis cases compared to controls. These genotypes included homozygosity IL-10-1082 G/G, IL-6-174 C/C and TNF-α-308 G/G. Thus, these may be considered susceptibale or risk genotypes subjects carrying these genotypes to develop the disease.
Also, this study revealed that certain cytokine gene polymorphisms were presented in a significant lower frequency among psoriasis cases compared to controls. These genotypes included heterozygosity, IL-6-174 G/C and TNF-α-308 G/A.Thus, these may be considered protective against the disease progression.