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Abstract
Changes in lifestyle and diet have resulted in an increased number of obese subjects. Obesity is currently an important causative factor of health-related problems as diabetes mellitus, cardiovascular diseases, cancer, and others. The possibility of preventing the onset of diabetes using herbal medicines, as mulberry and others has recently attracted more attention.
In this work, the prophylactic and the therapeutic effect of mulberry leave extract and acarbose, on HF-induced obesity and insulin resistance in rats have been studied. The prophylactic effect was investigated by co-administration of both drugs for 60 days concurrently with the high fat diet. Also, in this study we investigated the effect of mulberry leaves extract and acarbose in the management of T2DM associated with obesity by co-administration of both drugs for 45 days concurrently with high fat diet to obese diabetic insulin resistant rats.
To achieve this goal, blood glucose, serum insulin and oral glucose tolerance were determined, while insulin resistance index and the ?-cell function % were calculated. In addition, serum levels of triglyceride, total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol and free fatty acids were also measured to give us a picture about the effect of high fat diet and the effect of drugs used in this study on fatty acid oxidation and lipolysis.
Moreover, we tried to investigate the antioxidant effect of the used drugs on the oxidative damage caused by HF diet induced-obesity by measuring glutathione content, glutathione peroxidase and superoxide dismutase enzyme activities.
To solve the mystery about the effect of HF diet and mulberry leaves extract on muscle glucose uptake and utilization and its relation to insulin resistance, isolated diaphragm method was used.
Besides, in the present work, we investigated sucrase enzyme inhibition by co-administration of sucrose with each of mulberry leaves extract or acarbose to either normal or obese diabetic insulin resistant rats.