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Abstract
NHLs are a collection of lymphoid malignancies with a diverse
pathology and natural history. This diversity is illustrated by the different
histologics ubtyPesa ndc lassificationosf NHLs that havea ppearedo vert he
years.
Tumor growth and metastasisa re angiogenesisd ependent’S witching
from angiogenesisin hibiting to angiogenesisst imulatingp henotypeu sually
accompaniedb y overexpressiono f one or more angiogenicf actors.
S-VEGF and S-bFGF are consideredt o be the most endothelialspecific
and the most relevant of the known angiogenic growth factors.
High pretreatmenlte vel of S-VEGFa nd S-bFGFa re associatedw ith
tumor active angiogenesisa nd poor prognosticf actors in relapseda nd/or
refractory aggressiveN HLs.
s-rc% of patientsw ith aggressiveN HLs donot respold to induction
therapya nd 5-15%o f patientsw ith aggressivNe HLs achieveo nly a partial
response and 20-40% of relapsed NHLs achieve a second CR after salvage
.tte*otttoapy, but l-fieo veratti ”.era:te being 5J0%’