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العنوان
Synthesis of some new Pyrimidine Derivates of possible Biological interest /
المؤلف
Osman, Nermine Awni Ahmed.
هيئة الاعداد
باحث / نرمين عوني احمد عثمان
مشرف / محمد العشماوي
مشرف / زكريا عبدالسميع
مشرف / سيد حسين الفقي
الموضوع
Pyrimidines- Synthesis.
تاريخ النشر
1999 .
عدد الصفحات
159 P. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الصيدلة ، علم السموم والصيدلانيات (المتنوعة)
تاريخ الإجازة
1/1/1999
مكان الإجازة
جامعة الزقازيق - كــليـــة الصيدلــــة - Department of Organic Chemistry.
الفهرس
Only 14 pages are availabe for public view

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Abstract

Pyrimidine-Biological Interest.
Pyrimidines are important class of organic compounds both as natural products and synthetic targets . Various types of synthesis and pharmacological properties of pyrimidine derivatives are reviewed .
This investigation describes the most suitable conditions for O- and N-alkylation of 4-methyl-6-phenylpyrimidine-2-ol by using ethyl bromoacetate . O-alkylation proceeds as the major pathway in ethanol containing sodium ethoxide . N-alkylation occurs as the alternative pathway in dimethylformamide containing sodium ethoxide .
Identification of the new compounds was substantiated by spectral data , elemental analysis and in some cases by unambiguous synthesis .