الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
Summary
Uncontrolled cellular proliferation is the hallmark of neoplasia. As tumors increase in their degree of malignancy, their rate of cellular proliferation increases. The measurement of proliferation potential in brain tumors and its possible prognostic significance has been one of the most extensively and aggressively pursued correlates of clinical outcome.
Quantification of microvessel density in a primary tumor specimen at the initial diagnosis of cancer may predict the risk of metastasis or recurrence. A positive correlation between tumor angiogenesis and risk of metastasis, tumor recurrence and death has been reported for a variety of tumors.
The aim of this work was to find a correlation between
cellular proliferation of glial tumors, angiogenesis and the tumor grade and hence the prognosis of the tumor. This retrograde study included 50 cases of glial tumors collected from Department of Pathology- Faculty of medicine- Zagazig, and Elmansoura Universities.
The clinical data of these cases were obtained from the patient sheets. The data included: the age of onset, sex, and site of tumor. Other data concerning the patient complaint, type of operation, and post operative follow up data were deficient.
Sections from paraffin blocks of these cases were stained with conventional hematoxylin and eosin stain and carefully examined microscopically to determine the type and histologic grade of the tumor according to W.H.O., 2000 classification of central nervous system tumors. Immunostaining was done using MIB-1 for cell proliferation, and CD31 for angiogenesis the results were measured using the image analyzer system CAS-200.
Cell proliferation as assessed in the present study by the use of MIB-1 labeling index was found to be correlated well with
the histopathological grading (W.H.O., 2000) of different glial tumors with good discrimination between low grade tumors e.g., pilocytic astrocytoma, fibrillary astrocytoma, oligodendroglioma, ependymoma, and high grade tumors e.g., anaplastic astrocytoma, glioblastoma multiforme, anaplastic oligodendroglioma, and anaplastic ependymoma.
Assessment of angiogenesis for the glial tumors examined in this study revealed a significant correlation between the histopathological grade and the degree of new vessel formation, with marked angiogenesis among high grade gliomas e.g., anaplastic astrocytoma, glioblastoma multiforme, anaplastic oligodendroglioma, and anaplastic ependymoma.
These results suggest that proliferative index and angiogenesis can be used as good tools to assess the prognosis in glial tumors.