الفهرس Only 14 pages are availabe for public view
 |  | from | 137 |  |  |
| | | from | 137 | | |
Abstract
Cystatin C is a low-molecular-mass protein (13.25kDa) accumulates in both the blood and plasmatic filtrates, Cystatin C has been demonstrated to specifically reflect impaired renal function, as it accumulates in the serum as the glomerular filtration rate decreases.
cystatin C is found in a variety of human body fluids, such as spinal fluid, milk, seminal plasma and broncho-alveolar lavage fluid In this clinical study, we provide data on the relationship between serum and pleural effusion levels of a number of high- and low-molecular-mass substances. We simultaneously measured levels of cystatin C, b2-microglobulin total proteins ,LDH in pleural effusion and serum, We determined cystatin C levels in pleural effusions and calculated the ratio of serum to pleural effusion levels of cystatin C, in order to discriminate between effusions caused by severe renal impairment and other types of effusion In this clinical study, we provide data on the relationship between serum and pleural effusion levels of a number of high- and low-molecular-mass substances. We simultaneously measured levels of cystatin C, b2-microglobulin total proteins ,LDH in pleural effusion and serum, We determined cystatin C levels in pleural effusions and calculated the ratio of serum to pleural effusion levels of cystatin C, in order to discriminate between effusions caused by severe renal impairment and other types of effusion All subject were undergone to the following investigations:
1-Through clinical examination
2-Serum and pleural total proteins.
3-Serum and pleural lactate dehydrogenase.
4-Serum and pleural cholesterol.
5-Serum creatinine .
6-Serum and pleural Cystatin C.
7-Serum and pleural ?2 microglobulin.
This study was carried out on 50 subjects with various causes of pleural effusion and 10 apparantly healthy individuals as healthy control.the subjects were divided in to two main groups:
Group 1: Healthy control subjects Composed of 10 Apparantly healthy individuals
Group 2: Subjects with various causes of pleural effusion:
They subdivided in to:
Group 2 (A): Renal group : consists of 10 subjects.
Group 2 (B): Hepatic group: consists of 12 subjects.
Group 2 (C): Parapneumonic group: consists of 10 subjects.
Group 2 (D): Malignant group: consists of 8 subjects.
Aim of the work:
To provide data on relationship between serum and pleural fluid levels of a number of high and low molecular mass substances such as Cystatin C,B2microglobulin total proteins,LDH to discriminate between pleural effusion due to renal insuficiency and other causes of pleural effusion Our result showed that Cystatin C concentrations in all patients were above the normal range for the serum of healthy adults. Extremely high concentrations of cystatin C in effusion/serum pairs were measured only in patients with renal failure , which clearly indicates a recognizable region characteristic of pleural effusion associated with renal failure.
we also established significant positive correlations between pleural effusion cystatin C and pleural effusion b2-microglobulin , Consistently high concentrations of cystatin C in serum/effusion pairs were found in patients with impaired renal function only. The levels of cystatin C and b2-microglobulin in pleural effusions showed significant correlations with that of serum creatinine.