الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Liver fibrosis results from chronic damage to the liver which is associated with significant morbidity and mortality, and occurs as a result of an exaggerated healing response triggered by chronic insults to the liver which may lead to cirrhosis. Traditionally, liver biopsy has been the ”gold standard” technique for diagnosing fibrosis and cirrhosis. As assessing the degree of fibrosis is important when making decisions about starting treatment, assessing treatment response, and screening for liver cancer, there is an urgent need for developing the new non–invasive methods. Noninvasive serum markers have been evaluated for the determination of fibrosis either singly or combined as a panel of markers. Diagnostic accuracy is greatest in studies using a panel together with an algorithm, which generates a predictive score and noninvasive diagnostic or imaging tests (e.g. Transient Elastography, Real Time Elastography, and Magnetic Resonance Imaging ) and genetic studies for assessing fibrosis have been evaluated.