الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
 |  | from | 213 |  |  |
| | | from | 213 | | |
Abstract
In this study we tried to evaluate aspirin , unfractionated heparin and fractionated heparin with the help of clinical scoring and MR imaging. The 48-hour time frame was chosen for this study in response to the concept that early therapeutic intervention would be more likely to decrease early recurrent events or clinical worsening. The incidence of hemorrhagic transformation in the three treatment groups demonstrated that there is no statistically significant difference between the three groups of treatment. We have to clear that throughout our study no systemic hemorrhage had occurred which does not go with some studies which demonstrated systemic hemorrhage as a complication of treatment especially with unfractionated heparin probably because of our relative small sample in each study group. The study has clarified that the larger the infarction volume the higher the incidence of hemorrhagic transformation , the clinical scoring consequently correlated with the incidence of hemorrhagic transformation Our results on the sensitivity of different MR imaging processes revealed that diffusion imaging was more sensitive than conventional MR imaging and considered as an ideal tool for early diagnosis of ischemic stroke . All results of the three treatment groups showed no significant difference regarding the clinical outcome but overall improvement in the final outcome . theses results may be partially attributed to the small number of patients and the relatively short period of follow up. Our results revealed that when intervention has made (with aspirin ,unfractionated heparin and LMWH ) early within the first 48 hours results in significant reduction in mortality and morbidity . So we recommend : • Early therapeutic intervention(with aspirin ,unfractionared heparin and LMWH) would be more likely to decrease early recurrent events or clinical worsening provided that contraindications such as allergy and gastrointestinal bleeding are absent, and the patient will not be treated with recombinant tissue-type plasminogen activator. • The use of diffusion and perfusion MR imaging in the early evaluation of ischemic stroke especially on application of early treatment . • Further similar future studies but with larger number of patients , longer period of follow up .