الفهرس 
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Abstract
This thesis is devoted to the development of new methods for the stability indicating analysis of certain compounds, namely: quetiapine, lacidipine, clopidogrel and aceclofenac in pure form, pharmaceutical dosage forms and/or biological fluids. The principles of the proposed procedures as well as the experimental parameters were studied, discussed and explained. Furthermore, the data given were statistically analyzed and compared with those obtained by comparison methods. The thesis is divided into five main parts. The first one involves a general introduction about stability-indicating methods, including a literature review of these methods and the objective of the work. The thesis also involves the development of three high performance liquid chromatographic methods for the stability indicating assay of some of the mentioned drugs in presence of their degradation products. One of them involved the use of micellar liquid chromatography. Some of these methods were exploited for the determination of some coadministered drugs, others were used for content uniformity testing and/or degradation kinetics. The last part of the thesis involves the use of chemometrics-assisted spectrophotometric methods using multivariate calibration for the stability indicating assay of aceclofenac in presence of its degradation product with application to synthetic mixtures and pharmaceutical tablets.
In all parts, the validation criteria and experimental parameters of the developed methods were intensively studied and explained. All the results obtained were statistically analyzed and compared with those given by comparison methods.