الفهرس 
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Abstract
The present study was conducted to throw the light on the effects of doramectin on pregnant rats and developing foeti during both the gestation and suckling period.The tested drug was subcutanously injected in a therapeutic dose (200ug/kg b.wt.) and double therapeutic dose (400ug/kg b.wt.).This study was coducted in three expermints: I – Effects of doramectin on developing foeti :- Thirty mature female albino rats were divided into three equal groups each of ten. The first group received sesame oil subcutaneously, on the 6th day of gestation as a control group. The second group received therapeutic dose of doramectin (200ug/kg b.wt.) subcutaneously, on the 6th day of pregnancy. The third group received double therapeutic dose of doramectin (400ug/kg B.wt.) subcutaneously, on the 6th day of pregnancy. Daily vaginal smears were examined and the female proved to be in oestrus was paired with a male in a separate cage. In the following morning a vaginal smear was taken to verify the first day of gestation. Presence of sperms in the obtained vaginal smear indicates zero day of gestation. On 20th day, each dam was weighed, slaughtered and caesarian sections were performed to determine the effects of the tested drug on foetal development by morphological, visceral, skeletal and histopathological examination. II- Effects of doramectin on mortality and growth rates of neonates during suckling period : Determination of body weight and both mortality and growth rates of neonates naturally delivered from pregnant rat administered therapeutic regimen of doramectin; (200 ug/ug B.wt.) subcutaneously, was studied on twenty female albino rats. After detection of pregnancy, the pregnant rats were divided into four equal groups each of five. The first group received sesame oil subcutaneously, pre-natal on the 6th day of pregnancy as a control group (a). The second group received sesame oil subcutaneously, post-natal on the 1st day after parturition as a control group (b). The third group received therapeutic dose of doramectin (200ug/kg B.wt.) subcutaneously, pre-natal on the 6th day of pregnancy . The fourth group received therapeutic dose of doramectin (200 ug/kg B.wt.) subcutaneously, post-natal on the 1st day after parturition. III - Cytogenetic effects of doramectinon pregnant rats and their neonates. Pregnant rats and suckling neonates obtained from dam rats in all suckling groups were intramuscularly injected with Colchicines ninety minutes before slughatering and both femurs were dissected to obtain bone marrow for culturing, for counting mitotic index and recording chromosomal damage. Administration of the therapeutic and the double therapeutic dose of doramectin evoked insignificant change in the mitotic index. from proceeding results it could be concluded that: In the light of our study, our data weigh up the evidence for the significant adverse effects of doramectin on the developing rat foeti and against their undue use in pregnant and lactating animals.