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العنوان
Epidemiology and prognostic factors in gastric carcinoma /
المؤلف
El-Gendy, Helmy Ezzat Ahmed.
هيئة الاعداد
باحث / حلمى عزت أحمد الجندى
مشرف / أحمد أحمد سلطـان
مشرف / نبيه أنور الغوالبى
مشرف / مصطفى محمد أبو زيد
مشرف / ثروت سعد قنديل
الموضوع
Stomach-- Cancer-- Epidemiology.
تاريخ النشر
2009.
عدد الصفحات
143 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
جراحة
تاريخ الإجازة
1/1/2009
مكان الإجازة
جامعة المنصورة - كلية الطب - Department of General Surgery
الفهرس
Only 14 pages are availabe for public view

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from 156

Abstract

Introduction: Gastric carcinoma remains a common disease worldwide with a dismal prognosis. It is an important cause of mortality and morbidity worldwide. Stomach cancer has different presentations according to the stage of tumor. In early gastric carcinoma, the symptoms could not be distinguished from the symptoms of peptic ulcer or gastritis. Lesions of the cardia may present with dysphagia and circumferential growths of the pyloric antrum cause obstructive symptoms and it is encountered more often with advanced than early lesions. Most gastric cancer patients are diagnosed with advanced disease, resulting in a dismal prognosis. This emphasies the importance of the identification of useful diagnostic and prognostic markers for gastric cancers in their earliest stages. Aim of work: The aim of the present study to predict factors that affected survival in patients with resectable gastric carcinoma. Patients and methods: Fifty operable patients with gastric carcinoma in our gastroenterology surgical center, Mansoura University, Egypt during the period from 2004 to 2007, were identified from a surgical database. This database was specifically designed for our surgical department to enable us to collect data retrospectively on surgical interventions and register complications as well as others details in the post operative period. This database includes demographic parameters, as well as data concerning therapeutic interventions and complications. Twenty eight patients underwent total radical gastrectomy with oesophago-jejunal anastomosis (roux – en – y) and 22 patients underwent subtotal radical gastrectomy with gastro-jejunal anastomosis (roux–en–y). Results: Young age and female sex carried low survival period. Stage IV and undifferentiated histological type carried poor prognosis than other types. General condition of the patients, pathological liver state, level of gastric resection had no implication on patients’ survival. P53 mutation and adjuvant chemotherapy did not have a role on patients’ survival. In the absence of metastatic spread, surgical resection remains the gold standard for the treatment of gastric cancer and the only chance for cure. Conclusions: For gastric carcinoma affecting the antrum or the body, it is better to do subtotal gastrectomy than total gastrectomy as it did not differ as regards patient survival. Dietetic habits, genetic coding and environmental conditions all playing and sharing in tumor behavior and rolling out the survival at all.