الفهرس 
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Abstract
With the hope to obtain new potential antioxidant and antitumor agents, we used curcumin as the lead compound and prepared different series of derivatives. Forty four compounds were prepared via different synthetic procedures, among them thirty one final compounds are considered new. The formation of the newly synthesized compounds was checked by TLC; and their structures were confirmed by elemental microanalysis, and some of them were studied for their IR, 1H-NMR, and mass spectroscopy. Forty of the synthesized compounds were tested for their capacities to scavenge the 2,2’-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS.+), and to protect human red blood cells (RBCs) from oxidative haemolysis. In addition, the percentage viability of different cell lines (Hep G2, WI38, VERO, and MCF-7) was tested. The results of the antitumor testing were generally in accordance with those of the antioxidant assays. Compounds which bear o-methoxy substitution to the 4-hydroxy function (61g, 59g, and 55g) exhibited significantly higher ABTS.+-scavenging, antihaemolysis, and antitumor activities than other derivatives. In addition, molecular modeling studies were carried out for biologically active and inactivehh compounds, to study the structure activity relationship, with the aim to elucidate which portions offff the molecules are critical for the antioxidant and antitumor activity.