الفهرس 
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Abstract
This dissertation focuses on the development of DNA-minor groove binders as antiparasitic agents. Parasitical diseases comprise some of the world’s largest health problems and yet current medication and treatments for these parasitical diseases are often difficult to administer, costly to the patients, and have disruptive side effects. Worse yet, these parasites are developing drug resistance, thus creating an urgent need for new treatments. Dicationic molecules constitute a class of antimicrobial drug candidates that possess high activity against various parasites. This thesis details the synthesis of different series of dicationic agents that were subjected to in vitro and in vivo screening against both Trypanosoma brucei rhodesiense (T.b.r.) and Plasmadium falciparum (P.f.).