الفهرس 
Introduction and aim of the work
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Abstract
The present study aimed at checking for the presence of FVL mutation among Egyptian cases affected with deep vein thrombosis, using accurate methods of molecular biology techniques as allele specific amplification refractory mutation system PCR (ARMS PCR) for diagnosis of cases and estimation of risk of the disease related to this mutation comparing the frequency of mutation among cases to normal population controls. Studied cases were represented by a cohort sample randomly selected 44 Egyptian cases of age ranging from 20 to 80 and sex of 16 males (36.4%) and 28 females (63.6%). These cases were taken from the cases presenting with DVT in the Intensive Care Units of surgery Department of Internal Medicine University Hospital as well as Ministry of Health Hospitals of Dakahlia Governorate, Egypt during the time from October 2006 to June 2007. For analysis of association and risk studies of FVL mutation, cases were compared to 211 healthy unrelated control subjects of matched age and sex. Conclusion FVL mutation is found in Egyptian cases with deep vein thrombosis. Allele specific amplification refractory mutation system PCR (ARMS PCR) is an accurate method for detection of FVL mutation in DVT cases. Frequency of FVL mutation among Egyptian cases with DVT is relatively high comparing to normal controls. Therefore recommend: Population screening for FVL mutation to detect of susceptible individuals for whom adequate programs, it is useful to prevent deep vein thrombosis. Also it is recommended for proper environmental behavior, combating pollution and stopping the bad health habits like smoking to protect individuals carrying the unfavorable genes making them susceptible to DVT. Extended travel, either by air or on land, increases the risk of blood clots. So Leg exercises and walking keep blood circulating, reducing the risk of venous stasis.