الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Introduction: Renal transplant recipients (RTRs) are regarded to be predisposed to oral candidosis. Aim of the work: This study was undertaken to evaluate the activity of hydrolytic enzymes in strains causing oral candidosis in RTRs and to compare it with that of immunocompetent patients. Materials and methods: A total of 123 Candida albicans and 10 C. krusei strains were isolated from 200 RTRs (39 RTRs suffered from symptomatic candidiasis, the remaining patients had no symptoms of infection). All fungi were identified based on routine mycological procedures. The activity of 19 hydrolytic enzymes was assessed by API ZYM® test. Results: *C. albicans from RTRs showed higher enzymatic activity compared to strains from immunocompetent patients. *Candida albicans was the most prevalent species from both RTRs and immunocompetent patients, followed by Candida krusei. * RTRs having oral candidosis were significantly younger than the immunocompetent patients. * The severity of oral candidosis was higher at earlier time after transplantation. *The usage of mycophenolate mofetil was connected with higher ratio of clinically apparent oral candidosis compared to remaining patients (74.4% vs. 46.8%, respectively, p<0.01). Conclusion: The enhanced enzymatic activity is responsible for higher invasiveness of Candida residing oral cavity of RTRs.